Partners

2. CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France www.cnrs.fr

The Institute of Organic and Analytical Chemistry (ICOA, UMR 3711 – University of Orléans – CNRS) is composed by 32 permanent researchers and 17 engineers, technicians and administratives and 71 non-permanent employees. ICOA is a research laboratory located on the campus of the University of Orleans in a modern, 4000 m² building. The main objective of the laboratory research activities is to design, synthetize and analyze novel bioactive molecules having potential applications as drugs or as components of cosmetic formulation. The scientific approach to these new molecules involves design by molecular modeling techniques, preparation by organic synthesis, with a particular emphasis on heterocyclic compounds, carbohydrate derivatives, chemoenzymatic synthesis and nucleoside analogs. Extraction of bioactive compounds from plant material are achieved by using varied approaches (pressurisated fluids, supercritical fluids).   High performance separation techniques (UHPLC, UHSFC), mass spectrometry analysis, and  enzymatic affinities are applied, in order to identify and characterize the biological targets of these molecules.

ICOA has numerous collaborations and partnerships  with many research laboratories (CBM, I3MTO, LBLGC, INEM, GREMI, GICC, etc.), with CEA (ICOA is an academic correspondent laboratory LRC M09), with pharmaceutical companies (Servier through the joint laboratory) and through Competitiveness Clusters  (Polepharma and Cosmetic Valley) in region centre Val de Loire. Since 2012, ICOA is a member of two Laboratory of Excellence (LabEx), SYNORG and IRON. ICOA is also involved in numerous international relationships with industrial and academic partners.

3. UNIVERSITE D’AVIGNON ET DES PAYS DE VAUCLUSE France http://www.univ-avignon.fr/fr.html

Université d’Avignon et des Pays de Vaucluse (UAPV) is a multi-displinary university, with a strong focus on Sciences and Agrosciences on the one hand and Culture and Heritage on the other hand, located in a beautiful environment. It offers study programmes from undergraduate to PhD level and produces high-quality research. It is a human-scale university with around 7000 students, 13% of whom are international students. It has a strong

experience of international cooperation and more than 150 partner institutions abroad, not only in the European Union but also worldwide, notably in Canada, Brazil and North Africa.

GREEN (Groupe de recherché en Eco Extraction des produits Naturels) is one of the four teams of the UMR408 (unité mixte de recherche) INRA-UAPV. Its main research is focused on green extraction processes and procedures including innovative processes and alternative solvents for the valorization of natural  products for cosmetic, food, nutraceutic, and perfumery industries. GREEN established in 2007 and retains its primary aim of securing and maintaining a position of international excellence in a variety of applications of green  extraction in chemistry and processing technologies.

It is a national and international resource base for topics related to green processes (microwave, ultrasound…) and alternative solvents (terpenes, edible oils…) and provides expertise on applications of green extraction to academic institutions, companies and government organisations. Much of this research has received French funding together with industrial sponsorships and has led to safer and more cost-effective chemical processes in the industry.

4. UNIVERSIDAD COMPLUTENSE DE MADRID Spain http://www.ucm.es

The Cardiovascular and Metabolic Research Group (CVMRG) belongs to the Departments of Physiology and Medicine at the Faculty of Medicine and Nutritio at the School of Pharmacy.CVMRG is included in the IdISSC (Biomedical Research Institute Foundation for Biomedical Research. San Carlos Hospital), and RIC (Cardiovascular Research Net, Institute of Health Carlos III). Main research activities are pathophysiology of cardiovascular and metabolic diseases, as well as mechanisms of action of drugs to control those diseases and mechanisms of action of polyphenols, terpenes, gingerols, fatty acids, etc.

5. CONSIGLIO NAZIONALE DELLE RICERCHE Italy www.cnr.it

IMC belongs to the Italian National Research Council (CNR) and is located at the Area della Ricerca di Roma 1 in Montelibretti (Rome). Its mission is the development of sustainable chemical processes in the field of separation sciences, food chemistry, life sciences and environmental chemistry. IMC has strong interactions with national and international research institutions and universities and cooperates with a variety of industrial partners.

6. ADSI-Austrian Drug Screening Institute GmbH Austria   www.adsi.ac.at

ADSI is a research institute founded in 2011, which focusses on the screening and identification of bioactive substances in plant extracts, primarily for their application in the pharmaceutical, cosmetic and food products. ADSI is owned by the University of Innsbruck (100% of shares) and is located at the academic campus of Innsbruck. ADSI is an integral part of the Austrian research landscape and works closely together with national and international academic institutions, as well as with industrial partners. The vision of the ADSI is to develop and offer a bundle of highly specialized analytical services and biological cell test systems accompanied by bioinformatics analysis. In particular, the combination of chemical and biological services is unique and allows high-quality research and development activities. ADSI performs in-house research and development and offers its services to phytopharma, dietary supplement companies, phytocosmetics, nutrition and related industries.

7. PHARMAGNOSE VIOTECHNOLOGIKI ANONYMI ETAIREIA Greece  www.pharmagnose.com

PharmaGnose S.A. (PhG) is a Spin Off company of the University of Athens specialized to offer a wide range of bioactive natural products, in the form of enriched extracts and pure compounds. Based on the 20 years experience of academic researchers, PhG has established extensive collaboration with pharmaceutical, cosmetic and agro-food industries being a supplier of R&D solutions in terms of products and services. It is specialized at the isolation of biologically active natural compounds, the search for new lead compounds, and the development of innovative products derived from natural sources. Implementing its vision for the sustainable utilization of Greek biodiversity, the last years PhG has invested in developing extraction protocols, analytical procedures and scale up production of high added value natural products using products and by-products of olive tree. Therefore, bioactive extracts as well as pure natural compounds have been developed and commercialized based on materials coming from the olive industry. PhG also performs in vitro biological assays for the anti-ageing evaluation of natural based materials.

8. UNI-PHARMA KLEON TSETIS PHARMACEUTICAL LABORATORIES S.A. Greece   www.uni-pharma.gr

Kleon Tsetis, a pharmacist with a vision to strengthen the position of Greek companies in the pharmaceutical industry, established Uni-Pharma in 1967 with the mission of improving the Quality of Life of our fellow men by facilitating Access to Treatment with Innovative, High-Quality and cost-efficient Pharmaceutical Products. Since its establishment, Uni-Pharma has been researching, developing, manufacturing and marketing pharmaceuticals of the highest quality, covering all major therapeutic areas, with innovation highlights such as APOTEL the world’s first injectable paracetamol drug  and SALOSPIR (the first acetylsalicylic acid-based product introduced in Europe in the form of enteric-coated tablets),  as well as technological challenges such as T4 (for the treatment of thyroid disorders, in 13 different concentrations).

Uni-Pharma’s vision is to be among the leaders of the constantly changing pharmaceutical landscape, by offering high quality products to patients worldwide.
Since its foundation, Uni-Pharma has grown from a small privately-held company into a large and dynamic organization, which currently holds the leading position in unit sales among Greek-owned companies in the domestic market, with almost  30 million Stock Keeping Unit sales which corresponds to a 22% market share.

Uni-Pharma employs 236 permanent staff in total ,10% of which is allocated to the strategic function of Innovation, 47% to that of Manufacturing, 34% to the strategic function of Customer Service and 8% to Key Supportive Activities. 30% of the Personnel comprises of tertiary education scientists, while 37% of those hold a post-graduate diploma.

Most prominent token of Uni-Pharma’s commitment in multi-dimensional business development and source of competitive advantage is its new state-of-the-art industrial plant in Attica inaugurated in 2015, which is the largest investment materialized in the Greek pharmaceutical field over the last 2 years. The new facilities are a model of safety, efficiency and automation. Bioclimatic design, allows a significant reduction of the site’s energy consumption footprint coupled with other best practices in the sustainability field, while being in full harmony with the surrounding environment, whereas fully automated and digitized production and control systems maximize effort and output. Total area of the site is approximately 9,500 m2 and its capacity reaches 2 billion tablets and 50 million parenteral dosage units, annually.

9. SERVIZO GALEGO DE SAUDE Spain www.sergas.es

The SERGAS (Servizo Galego de Saude) is an autonomous administrative body responsible for the management and provision of health services in the Public National Health Care system in the Region of Galicia (Population: 2.772.533). It includes a network of 14 hospitals, 3 of them university hospitals, 457 primary health care centers and more than 37.000 workers (7314 physicians). Biomedical research and development is one of the most important activities in the SERGAS. The NEIRID Group, The Molecular and Cellular Cardiology Group and the Musculo-Skeletal Pathology group of SERGAS are based at Santiago University Clinical Hospital at the Instituto de Investigación Sanitaria de Santiago (IDIS) and headed in the OLIVENET project by Dr. Oreste Gualillo. The primary research of these groups focussed on the molecular signals triggered by hormones, drugs and natural products in rheumatic, cardiovascular, and muscle-skeletal inflammatory and immunometabolic diseases.

10. NATAC BIOTECH SL Spain  www.natac.es

NATAC BIOTECH S.L. is an SMEs with headquarters in Spain and international presence in LATAM and the USA. Natac is a leading biotechnology-based company specialized in the research & development, production and commercialization of high added value bioactive ingredients from agriculture products and biomass, to serve the needs of different industrial sectors. The success achieved so far can be ascribed to our rapid entrance and consolidation in the pharma, nutraceutical, cosmetic, food and feed markets. Natac’s idea is employing scientific knowledge to develop herbal extracts with scientifically supported bioactivities.

We are specialized in the most innovative extraction and purification technologies, such as pressurized liquid extraction, supercritical fluid extraction, ultrasonic assisted extraction, semipermeable membrane purification, differential solubility purification and crystallization and chromatographic purification among others. We design and coordinates the whole process from the botanical matrix to the final ingredient, including the extraction and functional characterization of the ingredients (in vitro, in vivo, pre-clinical and clinical trials).

Natac has developed an innovative business bioeconomic model based in the valorisation of agro-industrial by-products through the production of high added value natural ingredients. Natac has specialized in the creation of multi-product integrated biorefineries from agricultural and forestall biomass. Olive has been our first success case for the production of industrially viable commercial products based in a continuous effort in R&D.

11. ALNuMed GmbH Germany  www.alnumed.com

ALNuMed is a provider of analytical services for quality assurance and control of food and natural products.

Our customers are food industry as well as cosmetics, pharmaceutical, and the whole range of natural products processing companies.

Our expertise is the application of magnetic resonance techniques, infrared spectroscopy, mass spectrometry, and high performance liquid chromatography.

Our aim is the assurance of quality of industrial and natural products.

We follow the entire production process with a complete set of analytical techniques that allow application of high-throughput procedures. We test variety, origin, and production procedures even on the level of end-products.

12. NEURO-SYS SAS France www.neuro-sys.fr

Neuro-Sys is a French pharmacology company that relies on the knowledge and experience of pharmacists and pharmacologists specialized in the research and development of molecules used to treat neurodegenerative diseases and more specifically:

• Alzheimer’s disease
• Parkinson’s disease
• Amyotrophic lateral sclerosis (ALS)

Neuro-Sys is specialized in the screening of neuro active molecules and mode of action research.

With our experts, Neuro-Sys is a privileged partner for the pharmaceutical industry and biotechnology companies developing neuroprotective and neurorehabilitation molecules.

Neuro-Sys is also capable of developing its own screening programs and make use of the results from studies initially conducted on drugs from selected traditional pharmacopoeia.

In parallel to our service activities, Neuro-Sys conducts its own R&D. We currently have three patents on the synergistic effect of several plant extracts.

13. ECOLE NATIONALE D’AGRICULTURE DE MEKNES Morocco www.enameknes.ac.ma

Agropole olivier center has been launched since 2010 thanks to a partnership between the national institute of agriculture (ENA) and the agro-industrial profession, and was supported by national and international public and private organizations. Agropole olivier is a center of competency and innovationfor the transfer of technology, the development and the promotion of the regional and national olive oil sector

Located in Meknes areas, olive tree cradle in Morocco, Agro-Pole Olivier provides the Moroccan olive sector with a scientific, technical and relational package for the promotion and sustainable development of this sector. Agro-Pole Olivier is a privileged junction for information exchanges,technical sharing and technological progress owed toolive network development more and more oriented towards innovation and quality improvement. Its main objectives can be summarized as the following:

1- Technical and technological completions transfer and popularization of the olive oil sector in order to contribute to the advancement and development of this sector by organizing Open-Doors Days and workshops on this thematic in favor of various olive industry operators, demonstration of cultural techniques, tasting courses and sensory analyzes etc.;

2- Research and development to respond to current preoccupations of the olive oil network (technological innovation, olive oil quality potential, by-products and olive biomass valorization, good practices of olive oil production …);

3-  Technical, technological, lawful, commercial and strategic monitoring for the olive oil network;            4- Tool for the “Olive Oil Meknes” and “Olive Oil Morocco” promotion (Tasting jury constituted by national and international members, contest of the best olive oil)            5- Establishment of an olive oil information system for the development of the olive network: technical, economic and financial data bases, quality and typicality of olive oil, etc.

Agro-Pole Olivier is an integrated entity including various links and activities of the olive tree sector: from the genetic material, nursery, to the olive oil production and by-products valorization (laboratories, orchards, crushing unit etc.).

14. INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE D ALGERIE Algeria  www.inraa.dz

INRAA (DZ) is an Algerian public research institution, founded in April 1966, affiliated to the Ministry of Agriculture and Rural Development (MADR) responsible at national level for the development of research and innovation programs in agriculture and Agri-food technology.

In accordance with its national mandate, INRAA’s activities are embedded mainly in the following fields: I) Knowledge and understanding of he physical environment. II) Development and improvement of field crops. III) Development and improvement of animal production. IV) Agrifood technology research (Preservation, processing of agricultural products and improving their quality). V) Biotechnology applied to agriculture. VI) Economics and sociology of agriculture and rural development. VII) Ecology and environment in relation to agricultural research.
For the implementation of its activities, INRAA has an annual budget of 6.5 million Euros (2013) and a significant budget for equipment
for a total staff of 600 people, among which 160 are researchers. INRAA is organized into research divisions and research units
positioned in research stations, all coordinated by a central administrative unit (INRAA Headquarter). During the last 5 years, INRAA has
developed many national and international programs in the agricultural related fields. Many of these projects have allowed INRAA to
acquire a leading position in the area and a great expertise in terms of research project management in Algeria. As a result, INRAA has
been appointed during 2010-2014 period as focal point for managing research programs in collaboration with the Ministries of Agriculture and Higher Education and Scientific Research (A set of 40 projects performed or/and monitored for a budget of 1,6 million Euros during ). Internationally, INRAA develops an intense cooperation activity, both multilateral and bilateral, with R & D organizations. Thus, during 2010-2018 period, INRAA was involved in 30 international projects performed in multilateral frameworks (European Union, International Agency for Atomic Energy, African Union, NEPAD, CGIAAR, FAO, UNDP, IFAD) and in bilateral frameworks (China, South Korea, Netherlands, Argentina, Brazil, Poland, Spain, Tunisia, Morocco). Furthermore, INRAA has a significant experience in FP 7 and H 2020 and other UE programs:

• Involvement into two FP 7 projects: FAWIRA (GA295088, 2012-2014) and CINEA (GA N° 609495). The last project was devoted to foster innovation and exploitation of results research in the agri-food domain in Algeria
• Involvement in a RISE project devoted to “Bioactive compounds from Olea europaea: investigation and application in food, cosmetic and pharmaceutical industry” (Olive-Net, GA N° 734899)
• Participation in “5 TOI 4EWAS” project (GA N°692523) entitled “Quintuple helix approach to targeted open innovation in energy, water, agriculture in the south Mediterranean neighborhood”.

15. RANGSIT UNIVERSITY Thailand  http://www.rsu.ac.th

Rangsit University, founded in 1986, is the top private university in Thailand and it is only private university which has been assessed on education standard quality by the Office for National Education Standards and Quality Assessment (Public Organization) and rated “Very Good”. Currently there are total of 141  programs; 94 undergraduate programs, 37 Master Degree programs, 1 Graduate Diploma and 9 Doctoral Degree programs. There are more than 20,000 students. The curriculums are broadly categorized into 5 groups under 30 faculties (or colleges) as follows;

1. Faculties of Medical and Health Sciences: College of Medicine, Faculty of Dentistry, College of Pharmacy, Faculty of Medical Technology, Faculty of Nursing Science, Faculty of Physical Therapy and Sport Science, Faculty of Science, Faculty of Optology and College of Oriental Medicine
2. Faculties of Engineering and Technology: College of Engineering, Faculty of Information Technology, College of Agricultural Innovation Food and Biotechnology, Institution of Aviation Accounting,  College of Tourism and Hospitality and Faculty of Economics
3. Faculties of Humanities and Social Sciences: College of Social Innovation, College of International, Institute of Diplomacy and International Studies, Faculty of Liberal Arts, Faculty of Communication Arts, Faculty of Law, Faculty of Education and Graduate School
4. Faculties of Art and Design: Conservatory of Music, Faculty of Architecture, Faculty of Arts and Design and Faculty of Digital Art
5. Faculties of Economics and Business Administration: College of Government, Faculty of Business Administration, Faculty of Accounting, College of Tourism and Hospitality and Faculty of Economics

A research team participated in the Olive-Net Project comes from College of Oriental Medicine, College of Pharmacy, and Faculty of Medical Technology. College of Oriental Medicine is a unique oriental medicine institution has a focus of intention in conservation and modernization of oriental medicine preparations by using advanced phytopharmaceutical technology and evidence-based medicine knowledge. There are 220 herbal medicines were developed and have been used successfully in a hospital.

16. UNIVERSITE D’ORLEANS France https://www.univ-orleans.fr/

The Institute of Organic and Analytical Chemistry (ICOA, UMR 3711 – University of Orléans – CNRS) is composed by 32 permanent researchers and 17 engineers, technicians and administratives and 71 non-permanent employees. ICOA is a research laboratory located on the campus of the University of Orleans in a modern, 4000 m² building. The main objective of the laboratory research activities is to design, synthetize and analyze novel bioactive molecules having potential applications as drugs or as components of cosmetic formulation. The scientific approach to these new molecules involves design by molecular modeling techniques, preparation by organic synthesis, with a particular emphasis on heterocyclic compounds, carbohydrate derivatives, chemoenzymatic synthesis and nucleoside analogs. Extraction of bioactive compounds from plant material are achieved by using varied approaches (pressurisated fluids, supercritical fluids).   High performance separation techniques (UHPLC, UHSFC), mass spectrometry analysis, and  enzymatic affinities are applied, in order to identify and characterize the biological targets of these molecules.

ICOA has numerous collaborations and partnerships  with many research laboratories (CBM, I3MTO, LBLGC, INEM, GREMI, GICC, etc.), with CEA (ICOA is an academic correspondent laboratory LRC M09), with pharmaceutical companies (Servier through the joint laboratory) and through Competitiveness Clusters  (Polepharma and Cosmetic Valley) in region centre Val de Loire. Since 2012, ICOA is a member of two Laboratory of Excellence (LabEx), SYNORG and IRON. ICOA is also involved in numerous international relationships with industrial and academic partners.